Also known as nucleotide reverse transcriptase inhibitors.Nucleotide analogues are chemically modified or ‘false’ nucleotides; the building blocks of RNA and DNA.Only one NtRTI is licensed – tenofovir.In the replication process, the HIV virus may utilise one of the ‘false’ blocks instead of a natural building block and thereby halt or inhibit viral replication.Nucleotide analogues are designed to activate quickly inside cells and persist for long periods of time, selectively targeting and interfering with key enzymes essential for viral replication.
